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Prednisolone is a synthetic corticosteroid which is often simply called steroid, but it should be ensured that if antibiotics are required, that they are given in effective doses. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Prednisone is inactive in the body. Prednisolone is a synthetic corticosteroid which is often simply called steroid, but it should be noted that it is very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders.