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If this is the person's first time on depression medication or if the dose has recently been changed. The person's first time on depression medication or if the dose has recently been changed. Often goes unnoticed in the elderly. Chronic inability to sleep could also cause depression. Recent studies have suggested that over a period of a year, many talking treatments are as effective as antidepressants, particularly in mild to moderate depression, although it's generally accepted that antidepressants work faster.