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Esomeprazole works best if taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. You how long it will take to feel the full benefit of Nexium. Nexium is usually taken once a day at least one hour before meals and at the same time every day. Esomeprazole is used to treat ulcers, gastroesophageal reflux disease, and other conditions caused by excess stomach acid.
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